HUMAN MUSCLE MACROPHAGES EXPRESS BETA-AMYLOID PRECURSOR AND PRION PROTEINS AND THEIR MESSENGER-RNAS

被引：18

作者：

ASKANAS, V

SARKOZI, E

BILAK, M

ALVAREZ, RB

ENGEL, WK

机构：

[1] Neuromuscular Center, Department of Neurology, University of Southern California School of Medicine, Los Angeles, CA, 90017

来源：

NEUROREPORT | 1995年 / 6卷 / 07期

关键词：

MACROPHAGES; HUMAN MUSCLE; BETA-APP; BETA-APP MESSENGER-RNA; PRION PROTEIN; PRION PROTEIN MESSENGER-RNA;

D O I：

10.1097/00001756-199505090-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WELL-CHARACTERIZED antibodies against beta-amyloid precursor protein (beta APP) and prion protein (PrP), and specific cRNA probes, were used to localize beta APP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of beta APP and PrP, and strongly expressed beta APP and PrP mRNAs. These were present in all muscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate beta APP and PrP. We suggest that those proteins play a role in biology of muscle macrophages, including their participation in inflammatory and immune responses.

引用

页码：1045 / 1049

页数：5

共 25 条

[1] PRION PROTEIN IS ABNORMALLY ACCUMULATED IN INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

BILAK, M ;

ENGEL, WK ;

ALVAREZ, RB ;

TOME, F ;

LECLERC, A .

NEUROREPORT, 1993, 5 (01) :25-28

[2]

ASKANAS V, 1992, AM J PATHOL, V141, P31

[3] STRONG IMMUNOREACTIVITY OF BETA-AMYLOID PRECURSOR PROTEIN, INCLUDING THE BETA-AMYLOID PROTEIN-SEQUENCE, AT HUMAN NEUROMUSCULAR-JUNCTIONS [J].

ASKANAS, V ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROSCIENCE LETTERS, 1992, 143 (1-2) :96-100

[4] BETA-AMYLOID PRECURSOR EPITOPES IN MUSCLE-FIBERS OF INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

ALVAREZ, RB ;

ENGEL, WK .

ANNALS OF NEUROLOGY, 1993, 34 (04) :551-560

[5] PRION PROTEIN IS STRONGLY IMMUNOLOCALIZED AT THE POSTSYNAPTIC DOMAIN OF HUMAN NORMAL NEUROMUSCULAR-JUNCTIONS [J].

ASKANAS, V ;

BILAK, M ;

ENGEL, WK ;

LECLERC, A ;

TOME, F .

NEUROSCIENCE LETTERS, 1993, 159 (1-2) :111-114

[6]

ASKANAS V, 1994, BRAIN PATHOL, V4, P322

[7]

BANKER BQ, 1994, MYOLOGY, P382

[8] MONOCLONAL-ANTIBODIES TO THE CELLULAR AND SCRAPIE PRION PROTEINS [J].

BARRY, RA ;

PRUSINER, SB .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (03) :518-521

[9] INVITRO MATURED HUMAN MACROPHAGES EXPRESS ALZHEIMERS BETA-A4-AMYLOID PRECURSOR PROTEIN INDICATING SYNTHESIS IN MICROGLIAL CELLS [J].

BAUER, J ;

KONIG, G ;

STRAUSS, S ;

JONAS, U ;

GANTER, U ;

WEIDEMANN, A ;

MONNING, U ;

MASTERS, CL ;

VOLK, B ;

BERGER, M ;

BEYREUTHER, K .

FEBS LETTERS, 1991, 282 (02) :335-340

[10] ANTIBODIES TO A SCRAPIE PRION PROTEIN [J].

BENDHEIM, PE ;

BARRY, RA ;

DEARMOND, SJ ;

STITES, DP ;

PRUSINER, SB .

NATURE, 1984, 310 (5976) :418-421

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