NEURONAL AND GLIAL GAMMA-AMINOBUTYRIC ACID+ TRANSPORTERS ARE DISTINCT PROTEINS

被引：51

作者：

MABJEESH, NJ

FRESE, M

RAUEN, T

JESERICH, G

KANNER, BI

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BIOCHEM,POB 1172,IL-91010 JERUSALEM,ISRAEL

[2] UNIV OSNABRUCK,DEPT ANIM PHYSIOL,W-4500 OSNABRUCK,GERMANY

来源：

FEBS LETTERS | 1992年 / 299卷 / 01期

关键词：

ASTROGLIAL CELL; MEMBRANE VESICLE; GABA TRANSPORT; IMMUNOFLUORESCENCE; SEQUENCE DIRECTED ANTIBODY; IMMUNOBLOTTING;

D O I：

10.1016/0014-5793(92)80109-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to beta-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to beta-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

引用

页码：99 / 102

页数：4

共 25 条

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