SYNTHETIC STUDIES ON LEINAMYCIN - A SYNTHESIS OF THE 1-OXO-1,2-DITHIOLAN-3-ONE MOIETY

被引：16

作者：

KANDA, Y ^{[1
]}

SAITO, H ^{[1
]}

FUKUYAMA, T ^{[1
]}

机构：

[1] RICE UNIV,DEPT CHEM,HOUSTON,TX 77251

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 39期

关键词：

D O I：

10.1016/0040-4039(92)89010-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the 1-oxo-1,2-dithiolan-3-one moiety of antitumor antibiotic leinamycin (1) is described. An intramolecular delivery of a sulfur atom (7 to 8) and a facile Beckmann fragmentation (10 to 12) constitute the backbone of our synthesis.

引用

页码：5701 / 5704

页数：4

共 7 条

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