DIRECT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY (HPLC) SEPARATION OF ETODOLAC ENANTIOMERS USING CHIRAL STATIONARY PHASES

被引：15

作者：

CACCAMESE, S

机构：

[1] Department of Chemical Sciences, University of Catania, Catania

来源：

CHIRALITY | 1993年 / 5卷 / 03期

关键词：

ETODOLAC; ENANTIOMERS; CHIRAL PHASES; ANTIINFLAMMATORY;

D O I：

10.1002/chir.530050311

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The enantiomers of the antiinflammatory drug Etodolac were separated without derivatization on Chiralcel OD and Pirkle (R)-DNBPG columns. Enantiomeric purity can be determined in less than 10 min. Optimization of separation was evaluated using various concentrations of 2-propanol (doped with TFA) in hexane as the mobile phase.

引用

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页码：164 / 167

页数：4

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