INTERACTION OF BRIDE OF SEVENLESS MEMBRANE-BOUND LIGAND AND THE SEVENLESS TYROSINE-KINASE RECEPTOR

被引：287

作者：

KRAMER, H ^{[1
]}

CAGAN, RL ^{[1
]}

ZIPURSKY, SL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA

来源：

NATURE | 1991年 / 352卷 / 6332期

关键词：

D O I：

10.1038/352207a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

引用

页码：207 / 212

页数：6

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