POTENTIAL BIOLOGICAL TARGETS FOR ANTI-ALZHEIMER DRUGS

被引：13

作者：

ALLAIN, H

BELLIARD, S

DECERTAINES, J

BENTUEFERRER, D

BUREAU, M

LACROIX, P

机构：

[1] HOP PONTCHAILLOU,SERV NEUROL,RENNES,FRANCE

[2] FAC MED RENNES,RESONANCE MAGNET BIOL & MED LAB,RENNES,FRANCE

[3] BIOTRIAL SA,RENNES,FRANCE

来源：

DEMENTIA | 1993年 / 4卷 / 06期

关键词：

ALZHEIMERS DISEASE; PHYSIOPATHOLOGY; CLINICAL TRIALS;

D O I：

10.1159/000107344

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The stunning accumulation of data on the physiopathology of Alzheimer's disease is a real hinderance to pharmacologists who have to make decisions as to what molecules should be assessed first in man. Considering the cumbersomeness and cost of clinical trials in that field, a review of potential targets for drugs that are supposed to be active against the disease has become necessary, for a true definition of the rational justifications of trials to be envisaged.

引用

页码：347 / 352

页数：6

共 63 条

[1] ALZHEIMER-DISEASE AMYLOID BETA-PROTEIN FORMS CALCIUM CHANNELS IN BILAYER-MEMBRANES - BLOCKADE BY TROMETHAMINE AND ALUMINUM
ARISPE, N
ROJAS, E
POLLARD, HB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) : 567 - 571
[2] CALCIUM-INDEPENDENT RELEASE OF AMINO-ACID NEUROTRANSMITTERS - FACT OR ARTIFACT
BERNATH, S
[J]. PROGRESS IN NEUROBIOLOGY, 1992, 38 (01) : 57 - 91
[3] ALZHEIMER DEMENTIA - QUANTIFICATION OF ENERGY-METABOLISM AND MOBILE PHOSPHOESTERS WITH P-31 NMR-SPECTROSCOPY
BOTTOMLEY, PA
COUSINS, JP
PENDREY, DL
WAGLE, WA
HARDY, CJ
EAMES, FA
MCCAFFREY, RJ
THOMPSON, DA
[J]. RADIOLOGY, 1992, 183 (03) : 695 - 699
[4] IDENTIFICATION AND CHARACTERIZATION OF A LARGE HUMAN BRAIN GENE WHOSE EXPRESSION IS INCREASED IN ALZHEIMER-DISEASE
BOYES, BE
WALKER, DG
MCGEER, PL
MCGEER, EG
[J]. MOLECULAR BRAIN RESEARCH, 1992, 12 (1-3): : 47 - 57
[5] BRANCONNIER RJ, 1986, AM J PSYCHIAT, V143, P1343
[6] AN ABNORMALITY OF PLASMA AMYLOID PROTEIN-PRECURSOR IN ALZHEIMERS-DISEASE
BUSH, AI
WHYTE, S
THOMAS, LD
WILLIAMSON, TG
VANTIGGELEN, CJ
CURRIE, J
SMALL, DH
MOIR, RD
LI, QX
RUMBLE, B
MONNING, U
BEYREUTHER, K
MASTERS, CL
[J]. ANNALS OF NEUROLOGY, 1992, 32 (01) : 57 - 65
[7] CHATELLIER G, 1991, DEMENTIA, V2, P200
[8] CORTICAL GABA-B AND GABA-A RECEPTORS IN ALZHEIMERS-DISEASE - A QUANTITATIVE AUTORADIOGRAPHIC STUDY
CHU, DCM
PENNEY, JB
YOUNG, AB
[J]. NEUROLOGY, 1987, 37 (09) : 1454 - 1459
[9] DEMENTIA - THE NEUROCHEMICAL BASIS OF PUTATIVE TRANSMITTER ORIENTATED THERAPY
COURT, JA
PERRY, EK
[J]. PHARMACOLOGY & THERAPEUTICS, 1991, 52 (03) : 423 - 443
[10] NEUROPROTECTIVE ACTIVITY OF CHLORMETHIAZOLE FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA IN THE GERBIL
CROSS, AJ
JONES, JA
BALDWIN, HA
GREEN, AR
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (02) : 406 - 411

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