POTENTIAL BIOLOGICAL TARGETS FOR ANTI-ALZHEIMER DRUGS

被引：13

作者：

ALLAIN, H

BELLIARD, S

DECERTAINES, J

BENTUEFERRER, D

BUREAU, M

LACROIX, P

机构：

[1] HOP PONTCHAILLOU,SERV NEUROL,RENNES,FRANCE

[2] FAC MED RENNES,RESONANCE MAGNET BIOL & MED LAB,RENNES,FRANCE

[3] BIOTRIAL SA,RENNES,FRANCE

来源：

DEMENTIA | 1993年 / 4卷 / 06期

关键词：

ALZHEIMERS DISEASE; PHYSIOPATHOLOGY; CLINICAL TRIALS;

D O I：

10.1159/000107344

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The stunning accumulation of data on the physiopathology of Alzheimer's disease is a real hinderance to pharmacologists who have to make decisions as to what molecules should be assessed first in man. Considering the cumbersomeness and cost of clinical trials in that field, a review of potential targets for drugs that are supposed to be active against the disease has become necessary, for a true definition of the rational justifications of trials to be envisaged.

引用

页码：347 / 352

页数：6

共 63 条

[21] N-METHYL-D-ASPARTATE ANTAGONISTS IN THE TREATMENT OF PARKINSONS-DISEASE
GREENAMYRE, JT
OBRIEN, CF
[J]. ARCHIVES OF NEUROLOGY, 1991, 48 (09) : 977 - 981
[22] NOVEL INHIBITORS OF IRON-DEPENDENT LIPID-PEROXIDATION FOR NEURODEGENERATIVE DISORDERS
HALL, ED
[J]. ANNALS OF NEUROLOGY, 1992, 32 : S137 - S142
[23] AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE
HARDY, J
ALLSOP, D
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) : 383 - 388
[24] ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS
HARDY, JA
HIGGINS, GA
[J]. SCIENCE, 1992, 256 (5054) : 184 - 185
[25] OKADAIC ACID INDUCES HYPERPHOSPHORYLATED FORMS OF TAU PROTEIN IN HUMAN BRAIN-SLICES
HARRIS, KA
OYLER, GA
DOOLITTLE, GM
VINCENT, I
LEHMAN, RAW
KINCAID, RL
BILLINGSLEY, ML
[J]. ANNALS OF NEUROLOGY, 1993, 33 (01) : 77 - 87
[26] HENDERSON V, 1989, J NEUROSURG, V79, P335
[27] THE CHOLINERGIC MODEL OF DEMENTIA, ALZHEIMER TYPE - PROGRESSION FROM THE UNITARY TRANSMITTER CONCEPT
HOLTTUM, JR
GERSHON, S
[J]. DEMENTIA, 1992, 3 (03): : 174 - 185
[28] AMMONIA IS ENDOGENOUSLY GENERATED IN THE BRAIN IN THE PRESENCE OF PRESUMED AND VERIFIED DEMENTIA OF ALZHEIMER TYPE
HOYER, S
NITSCH, R
OESTERREICH, K
[J]. NEUROSCIENCE LETTERS, 1990, 117 (03) : 358 - 362
[29] THE SEMINAL ROLE OF BETA-AMYLOID IN THE PATHOGENESIS OF ALZHEIMER-DISEASE
JOACHIM, CL
SELKOE, DJ
[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1992, 6 (01) : 7 - 34
[30] ALZHEIMER PLAQUES AND TANGLES - ADVANCES ON BOTH FRONTS
KOSIK, KS
[J]. TRENDS IN NEUROSCIENCES, 1991, 14 (06) : 218 - 219

← 1 2 3 4 5 6 7 →