LOCALIZATION OF THE TP53 GENE ON SYRIAN-HAMSTER CHROMOSOME-9 BY FLUORESCENCE IN-SITU HYBRIDIZATION

被引：5

作者：

POPESCU, NC

ZIMONJIC, DB

ALBOR, A

NOTARIO, V

机构：

[1] GEORGETOWN UNIV,MED CTR,VINCENT T LOMBARDI CANC RES CTR,DEPT RADIAT MED,DIV EXPTL CARCINOGENESIS,WASHINGTON,DC 20007

[2] NCI,BIOL LAB,BETHESDA,MD 20892

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 68卷 / 1-2期

关键词：

D O I：

10.1159/000133893

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutations of the Tp53 tumor suppressor gene have been detected in 50% of all human cancers. The normal Tp53 gene product acts as a negative regulator of cell division or is associated with abnormal growth in certain differentiated cell types. The Tp53 gene was mapped by FISH to Syrian hamster chromosome 9 bands qb2.2-->2.3 using a genomic DNA probe with a high degree of sequence identity to the human Tp53 gene.

引用

页码：71 / 73

页数：3

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