SIMILAR AGE-RELATED INCREASE OF VASOPRESSIN COLOCALIZATION IN PARAVENTRICULAR CORTICOTROPIN-RELEASING HORMONE NEURONS IN CONTROLS AND ALZHEIMER PATIENTS

被引：32

作者：

RAADSHEER, FC

TILDERS, FJH

SWAAB, DF

机构：

[1] GRAD SCH NEUROSCI, AMSTERDAM, NETHERLANDS

[2] FREE UNIV AMSTERDAM, FAC MED, NEUROSCI RES INST, DEPT PHARMACOL, 1081 BT AMSTERDAM, NETHERLANDS

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1994年 / 6卷 / 02期

关键词：

CORTICOTROPIN-RELEASING HORMONE; VASOPRESSIN; HUMAN PARAVENTRICULAR NUCLEUS; HYPOTHALAMO-PITUITARY-ADRENAL AXIS; ALZHEIMERS DISEASE;

D O I：

10.1111/j.1365-2826.1994.tb00563.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies on experimental animals showed that long term activation of the hypothalamo-pituitary-adrenal axis is associated with increased vasopressin (AVP) colocalization in paraventricular corticotropin-releasing hormone (CRH) neurons. In the present study we estimated the fraction of CRH neurons in which AVP is colocalized by double label immunocytochemistry in hypothalami of 10 control subjects of 21-91 years of age and 10 age-matched Alzheimer patients. CRH neurons in the paraventricular nucleus (PVN) of Alzheimer patients and control subjects showed similar age dependent increases in AVP colocalization. Based on this parameter, it seems that CRH neurons of Alzheimer patients are not overactivated as compared to age-matched controls, but e.g. changes in m-RNA for CRH should still be established.

引用

页码：131 / 133

页数：3

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