INTERACTIONS BETWEEN INTERLEUKIN-1 AND BASIC FIBROBLAST GROWTH-FACTOR ON ARTICULAR CHONDROCYTES - EFFECTS ON CELL-GROWTH, PROSTANOID PRODUCTION, AND RECEPTOR MODULATION

被引：20

作者：

CHIN, JE ^{[1
]}

HATFIELD, CA ^{[1
]}

KRZESICKI, RF ^{[1
]}

HERBLIN, WF ^{[1
]}

机构：

[1] DUPONT CO,DEPT MED PROD,WILMINGTON,DE 19898

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 03期

关键词：

D O I：

10.1002/art.1780340309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The interactions of interleukin-1-beta (IL-1-beta) and basic fibroblast growth factor (bFGF) with monolayer cultures of rabbit articular chondrocytes were examined. Both agonists resulted in a synergistic increase in prostanoid production, to levels higher than the maximal level for either protein alone. The synergy was time- and dose-dependent, was augmented in serum-free medium, and was blocked by indomethacin or a polyclonal antibody to IL-1-beta. The proteins had opposite effects on cell growth, and IL-1-beta completely blocked the mitogenic effect of bFGF. Pretreatment of cells with IL-1-beta induced a down-regulation in the number of the bFGF high-affinity receptors. Pretreatment of cells with bFGF increased the number of IL-1 receptors, which was dependent on messenger RNA synthesis.

引用

页码：314 / 324

页数：11

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