TEC HOMOLOGY (TH) ADJACENT TO THE PH DOMAIN

被引：99

作者：

VIHINEN, M

NILSSON, L

SMITH, CIE

机构：

[1] KAROLINSKA INST,NOVUM,CTR BIOTECHNOL,S-14157 HUDDINGE,SWEDEN

[2] KAROLINSKA INST,NOVUM,CTR STRUCT BIOCHEM,S-14157 HUDDINGE,SWEDEN

[3] UNIV TURKU,DEPT BIOCHEM,SF-20500 TURKU,FINLAND

[4] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

来源：

FEBS LETTERS | 1994年 / 350卷 / 2-3期

关键词：

BTK; BRUTONS AGAMMAGLOBULINEMIA TYROSINE KINASE; SIGNAL TRANSDUCTION; CYTOPLASMIC TYROSINE KINASE; XLA; X-LINKED AGAMMAGLOBULINEMIA;

D O I：

10.1016/0014-5793(94)00783-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.

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收藏

页码：263 / 265

页数：3

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