TEC HOMOLOGY (TH) ADJACENT TO THE PH DOMAIN

被引:99
作者
VIHINEN, M
NILSSON, L
SMITH, CIE
机构
[1] KAROLINSKA INST,NOVUM,CTR BIOTECHNOL,S-14157 HUDDINGE,SWEDEN
[2] KAROLINSKA INST,NOVUM,CTR STRUCT BIOCHEM,S-14157 HUDDINGE,SWEDEN
[3] UNIV TURKU,DEPT BIOCHEM,SF-20500 TURKU,FINLAND
[4] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN
关键词
BTK; BRUTONS AGAMMAGLOBULINEMIA TYROSINE KINASE; SIGNAL TRANSDUCTION; CYTOPLASMIC TYROSINE KINASE; XLA; X-LINKED AGAMMAGLOBULINEMIA;
D O I
10.1016/0014-5793(94)00783-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.
引用
收藏
页码:263 / 265
页数:3
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