AN EFFICIENT SYNTHESIS OF AN ANGIOTENSIN-II ANTAGONIST (A-81988)

被引：7

作者：

KERDESKY, FAJ

HAIGHT, A

NARAYANAN, BA

NORDEEN, CW

SCARPETTI, D

SEIF, LS

WITTENBERGER, S

MORTON, HE

机构：

[1] Process Research. Department 45L, Pharmaceutical Products Division Abbott Laboratories, Illinois 60064, Abbott Park

来源：

SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 14期

关键词：

D O I：

10.1080/00397919308009863

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient synthesis of A-81988, an angiotensin II antagonist, is described. The preparation utilizes a novel method for tetrazole formation from nitriles requiring trimethylsilyl azide and a catalytic amount of dialkyltin oxide.

引用

页码：2027 / 2039

页数：13

共 9 条

[1]

ALDRICH PE, 1989, Patent No. 4870186

[2] DISCOVERY OF A NOVEL CLASS OF ORALLY ACTIVE, NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS [J].

DE, B ;

WINN, M ;

ZYDOWSKY, TM ;

KERKMAN, DJ ;

DEBERNARDIS, JF ;

LEE, J ;

BUCKNER, S ;

WARNER, R ;

BRUNE, M ;

HANCOCK, A ;

OPGENORTH, T ;

MARSH, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (20) :3714-3717

[3] REACTION OF OXAZOLINES WITH PHOSPHORUS OXYCHLORIDE [J].

DORDOR, IM ;

MELLOR, JM .

TETRAHEDRON LETTERS, 1983, 24 (13) :1437-1440

[4] THE DISCOVERY OF DUP-753, A POTENT, ORALLY ACTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST [J].

DUNCIA, JV ;

CARINI, DJ ;

CHIU, AT ;

JOHNSON, AL ;

PRICE, WA ;

WONG, PC ;

WEXLER, RR ;

TIMMERMANS, PBMWM .

MEDICINAL RESEARCH REVIEWS, 1992, 12 (02) :149-191

[5] AN IMPROVED SYNTHESIS OF 5-SUBSTITUTED TETRAZOLES [J].

FINNEGAN, WG ;

HENRY, RA ;

LOFQUIST, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (15) :3908-3911

[6]

LUITJEN JG, 1963, RECL TRAV CHIM PAY B, V81, P286

[7] XANTHONES AND THIOXANTHONES .4. THE PREPARATION AND PROPERTIES OF 9-OXA-1-AZA-ANTHRONE AND 9-THIA-1-AZA-ANTHRONE [J].

MANN, FG ;

REID, JA .

JOURNAL OF THE CHEMICAL SOCIETY, 1952, (JUN) :2057-2062

[8]

MEYERS AI, 1975, J AM CHEM SOC, V97, P7383, DOI 10.1021/ja00858a034

[9]

WITTENBERGER SJ, UNPUB

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