PANCREATIC TRIGLYCERIDE LIPASE AND COLIPASE - INSIGHTS INTO DIETARY-FAT DIGESTION

被引：130

作者：

LOWE, ME

机构：

[1] Division of Gastroenterology and Nutrition, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO

来源：

GASTROENTEROLOGY | 1994年 / 107卷 / 05期

关键词：

D O I：

10.1016/0016-5085(94)90559-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Dietary fats have an impact on health and disease. A pancreatic exocrine protein, pancreatic triglyceride lipase, is essential for the efficient digestion of dietary fats. This enzyme requires another pancreatic exocrine protein, colipase, for full activity in the gut lumen. In addition to its importance in fat digestion, pancreatic triglyceride lipase has potential applications in medical therapy, medical diagnostics, and industry. This potential stimulated interest in lipases; radiograph during the last few years, studies applying the technologies of molecular biology and radiograph crystallography greatly increased our knowledge about pancreatic triglyceride lipase and colipase protein structure, enzyme mechanism, and gene structure. This review focuses on these recent advances and discusses models for the kinetic properties of pancreatic triglyceride lipase and for the interaction of pancreatic triglyceride lipase with colipase.

引用

页码：1524 / 1536

页数：13

共 108 条

[11] ADAPTATION OF THE EXOCRINE PANCREAS TO DIET [J].

BRANNON, PM .

ANNUAL REVIEW OF NUTRITION, 1990, 10 :85-105

[12] SUBSTRATE SPECIFICITY OF PANCREATIC LIPASE [J].

BROCKERHOFF, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 159 (02) :296-+

[13] SUBSTRATE SPECIFICITY OF PANCREATIC LIPASE INFLUENCE OF STRUCTURE OF FATTY ACIDS ON REACTIVITY OF ESTERS [J].

BROCKERHOFF, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 212 (01) :92-+

[14] A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX [J].

BRZOZOWSKI, AM ;

DEREWENDA, U ;

DEREWENDA, ZS ;

DODSON, GG ;

LAWSON, DM ;

TURKENBURG, JP ;

BJORKLING, F ;

HUGEJENSEN, B ;

PATKAR, SA ;

THIM, L .

NATURE, 1991, 351 (6326) :491-494

[15] SECRETION AND CONTRIBUTION TO LIPOLYSIS OF GASTRIC AND PANCREATIC LIPASES DURING A TEST MEAL IN HUMANS [J].

CARRIERE, F ;

BARROWMAN, JA ;

VERGER, R ;

LAUGIER, R .

GASTROENTEROLOGY, 1993, 105 (03) :876-888

[16] DIRECT INVOLVEMENT OF THE C-TERMINAL EXTREMITY OF PANCREATIC LIPASE (403-449) IN COLIPASE BINDING [J].

CHAILLAN, C ;

KERFELEC, B ;

FOGLIZZO, E ;

CHAPUS, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (01) :206-211

[17] MINIREVIEW ON PANCREATIC LIPASE AND COLIPASE [J].

CHAPUS, C ;

ROVERY, M ;

SARDA, L ;

VERGER, R .

BIOCHIMIE, 1988, 70 (09) :1223-1234

[18] THE LIPOPROTEIN LIPASE-ENCODING HUMAN GENE - SEQUENCE FROM INTRON-6 TO INTRON-9 AND PRESENCE IN INTRON-7 OF A 40-MILLION-YEAR-OLD ALU SEQUENCE [J].

CHUAT, JC ;

RAISONNIER, A ;

ETIENNE, J ;

GALIBERT, F .

GENE, 1992, 110 (02) :257-261

[19]

CYGLER M, 1993, PROTEIN SCI, V2, P366

[20]

DATTA S, 1988, J BIOL CHEM, V263, P1107

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