PECTIN ISOLATED FROM PRICKLY PEAR (OPUNTIA SP) MODIFIES LOW-DENSITY-LIPOPROTEIN METABOLISM IN CHOLESTEROL-FED GUINEA-PIGS

被引:53
作者
FERNANDEZ, ML
TREJO, A
MCNAMARA, DJ
机构
[1] UNIV ARIZONA,NUTR SCI PROGRAM,TUCSON,AZ 85721
[2] IPN,CIIDIR,MICHOACAN 59510,MEXICO
关键词
Dietary cholesterol; Guinea pigs; Hepatic HMG-CoA reductase; Low density lipoprotein; Pectin;
D O I
10.1093/jn/120.11.1283
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The effect of prickly pear soluble fiber on low density lipoprotein (LDL) metabolism was investigated by feeding male guinea pigs either a nonpurified diet containing 0.25% cholesterol (HC diet) or the HC diet + 1% prickly pear pectin (HC-P diet). Plasma cholesterol levels were significantly decreased by the HC-P diet, with a 33% decrease in LDL levels (p < 0.02) and an increase in LDL density. Hepatic free and esterified cholesterol levels were reduced 40 and 85%, respectively (p < 0.002), by the HC-P diet. Hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase levels were not different. 125I-LDL binding to hepatic membranes was increased 1.7-fold by the HC-P diet (p < 0.001), with receptor affinity (K(d)) being unaltered and receptor number (B(max)) being significantly increased (p < 0.001). These data suggest that prickly pear pectin may act by a mechanism similar to that of bile acid-binding resins in lowering plasma cholesterol levels. The observed reduction in LDL and hepatic cholesterol levels and increase in LDL density and hepatic apolipoprotein B/E receptors are responses suggesting an increased demand on hepatic cholesterol from increased excretion of bile acids and interruption of the enterohepatic circulation.
引用
收藏
页码:1283 / 1290
页数:8
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