ANALYSIS OF THE DOPAMINE-RECEPTOR FAMILY IN THE COMPACT GENOME OF THE PUFFER FISH FUGU RUBRIPES

被引：49

作者：

MACRAE, AD ^{[1
]}

BRENNER, S ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT MED,MOLEC GENET UNIT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

GENOMICS | 1995年 / 25卷 / 02期

关键词：

D O I：

10.1016/0888-7543(95)80044-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genome of the puffer fish, Fugu rubripes (Fugu), is approximately 400 Mb, 7.5 times smaller than that of human. We have isolated four dopamine receptorlike genes from Fugu genomic DNA. These genes show high sequence and structural homology to the known dopamine receptor genes, although, in contrast to previously described genes from this species, the intron size is comparable to that in human. The 5' noncoding exons of the D-2/D-3 dopamine receptor-like genes is described and compared to that in human. The high gene density of Fugu is shown by the close proximity of a cystatin-like gene 1503 bp from the dopamine receptor gene D222. We propose that the compact genome of Fugu can serve as a model for identifying gene family members directly from genomic DNA. (C) 1995 Academic Press, Inc.

引用

页码：436 / 446

页数：11

共 55 条

[1] EVIDENCE FOR A COMPLEX REGULATORY ARRAY IN THE 1ST INTRON OF THE HUMAN ADENOSINE-DEAMINASE GENE [J].

ARONOW, B ;

LATTIER, D ;

SILBIGER, R ;

DUSING, M ;

HUTTON, J ;

JONES, G ;

STOCK, J ;

MCNEISH, J ;

POTTER, S ;

WITTE, D ;

WIGINTON, D .

GENES & DEVELOPMENT, 1989, 3 (09) :1384-1400

[2] INHIBITION OF INTRACTABLE NUCLEASES WITH RIBONUCLEOSIDE-VANADYL COMPLEXES - ISOLATION OF MESSENGER RIBONUCLEIC-ACID FROM RESTING LYMPHOCYTES [J].

BERGER, SL ;

BIRKENMEIER, CS .

BIOCHEMISTRY, 1979, 18 (23) :5143-5149

[3] CHARACTERIZATION OF THE PUFFERFISH (FUGU) GENOME AS A COMPACT MODEL VERTEBRATE GENOME [J].

BRENNER, S ;

ELGAR, G ;

SANDFORD, R ;

MACRAE, A ;

VENKATESH, B ;

APARICIO, S .

NATURE, 1993, 366 (6452) :265-268

[4] CLONING AND EXPRESSION OF A RAT D2 DOPAMINE RECEPTOR CDNA [J].

BUNZOW, JR ;

VANTOL, HHM ;

GRANDY, DK ;

ALBERT, P ;

SALON, J ;

CHRISTIE, MJ ;

MACHIDA, CA ;

NEVE, KA ;

CIVELLI, O .

NATURE, 1988, 336 (6201) :783-787

[5] COUPLING OF D2 DOPAMINE-RECEPTORS AND D3 DOPAMINE-RECEPTORS TO G-PROTEINS [J].

CASTRO, SW ;

STRANGE, PG .

FEBS LETTERS, 1993, 315 (03) :223-226

[6] GENOMIC SEQUENCING [J].

CHURCH, GM ;

GILBERT, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :1991-1995

[7]

COKER GT, 1990, NEUROLOGY NEUROBIOLO, V57, P43

[8] MOLECULAR-CLONING AND EXPRESSION OF THE GENE FOR A HUMAN D1 DOPAMINE RECEPTOR [J].

DEARRY, A ;

GINGRICH, JA ;

FALARDEAU, P ;

FREMEAU, RT ;

BATES, MD ;

CARON, MG .

NATURE, 1990, 347 (6288) :72-76

[9] STRUCTURE AND LINKAGE OF THE D2 DOPAMINE RECEPTOR AND NEURAL CELL-ADHESION MOLECULE GENES ON HUMAN CHROMOSOME-11Q23 [J].

EUBANKS, JH ;

DJABALI, M ;

SELLERI, L ;

GRANDY, DK ;

CIVELLI, O ;

MCELLIGOTT, DL ;

EVANS, GA .

GENOMICS, 1992, 14 (04) :1010-1018

[10]

FRAIL DE, 1993, MOL PHARMACOL, V44, P1113

← 1 2 3 4 5 6 →