COMPARISON OF MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON THE SEPARATION AND DETERMINATION OF CAFFEINE AND ITS ANALOGS IN PHARMACEUTICAL TABLETS

被引：20

作者：

SUN, P

MARIANO, GJ

BARKER, G

HARTWICK, RA

机构：

[1] Department of Chemistry, State University of New York at Binghamton, Binghamton

来源：

ANALYTICAL LETTERS | 1994年 / 27卷 / 05期

关键词：

MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; CAFFEINE; THEOPHYLLINE; THEOBROMINE;

D O I：

10.1080/00032719408007362

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Micellar electrokinetic capillary chromatography (MEKC) is investigated for the separation and determination of caffeine and its analogues as a complementary method to high-performance liquid chromatography (HPLC). Separation efficiency, resolution, analysis time, sample recovery and reproducibility are examined by comparing MEKC and HPLC in parallel analysis. The results show that MEKC is a useful economic technique in pharmaceutical analysis, yielding high efficiency, resolution and short analysis times.

引用

页码：927 / 937

页数：11

共 14 条

[1] EXTENSION OF ELUTION RANGE IN MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].