THE MUTAGENICITY OF NITRITE IN THE SALMONELLA MICROSOME TEST SYSTEM

被引：15

作者：

BALIMANDAWA, M ^{[1
]}

DEMEESTER, C ^{[1
]}

LEONARD, A ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,TERATOGEN & MUTAGEN UNIT,UCL 7237,AVE E MOUNIER 72,B-1200 BRUSSELS,BELGIUM

来源：

MUTATION RESEARCH | 1994年 / 321卷 / 1-2期

关键词：

NITRITES; MUTAGENICITY; AMES TEST;

D O I：

10.1016/0165-1218(94)90114-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The bacterial strains of Salmonella typhimurium used for detection of base-pair substitutions (TA1530, TA1535, TA100 and TA102) and various types of frameshift mutations (YG1024, DJ400 and DJ460) were exposed to nitrites in the Salmonella/microsome test system. In agreement with published data, nitrites exhibited mutagenic activity in standard strains TA1530, TA1535 and TA100. The TA102 strain was insensitive as were the frameshift tester strains despite their genetically manipulated genome increasing their sensitivity.

引用

页码：7 / 11

页数：5

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