Role of RNA-Binding Proteins in Colorectal Carcinogenesis

被引：9

作者：

Anant, Shrikant ^{[1
,2
]}

Houchen, Courtney W. ^{[1
]}

Pawar, Vaibhav ^{[1
]}

Ramalingam, Satish ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Sect Digest Dis & Nutr, 920 Stanton L Young Blvd WP1345, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Cell Biol, Oklahoma City, OK 73104 USA

来源：

CURRENT COLORECTAL CANCER REPORTS | 2010年 / 6卷 / 02期

关键词：

Colon cancer; Gene regulation; Posttranscriptional regulation; RNA stability; mRNA translation; mRNA binding proteins; Protooncogenes; Protein: nucleic acid interactions; Protein: protein interactions; Cyclooxygenase-2; HuR; Tristetraprolin; CUGBP2; Musashi-1;

D O I：

10.1007/s11888-010-0048-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

RNA-binding proteins (RBPs) play key roles in the posttranscriptional regulation of gene expression. RBPs control various posttranscriptional events, including splicing, polyadenylation, mRNA stability, transport, and translation. It is becoming apparent that RBPs play a significant role in pathophysiologic conditions such as inflammation and cancer. More importantly, we and others have begun dissecting the role of mRNA stability and translation in regulating gene expression, dysregulation of which has serious consequences for the fate of the cell. In this article, we discuss this emerging area of posttranscriptional gene regulation and the role of RBPs in the aberrant expression of proteins in tumorigenesis.

引用

页码：68 / 73

页数：6

共 46 条

[1]

S1 ribosomal protein functions in translation initiation and ribonuclease RegB activation are mediated by similar RNA-protein interactions [J].