REPRESENTATION OF PHASE-EQUILIBRIUM BEHAVIOR OF ANTIBIOTICS

被引：16

作者：

ZHU, Y ^{[1
]}

EVANS, LB ^{[1
]}

CHEN, CC ^{[1
]}

机构：

[1] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139

来源：

BIOTECHNOLOGY PROGRESS | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1021/bp00004a006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The phase equilibrium behavior of biomolecules is important both in understanding the partition mechanisms and in the design and optimization of downstream recovery processes. Chen et al. (1989) proposed a molecular thermodynamic framework that successfully represents the liquid‐solid equilibrium behavior of amino acids and small peptides as functions of temperature, ionic strength, solvent compositions, and pH. Based on this theoretical framework, this paper presents recent results in representing the liquid‐solid equilibrium behavior (solubilities) and the liquid‐liquid equilibrium behavior (phase partitioning) of β‐lactam antibiotics, which are amino acid derivatives and important chemotherapeutic agents. Copyright © 1990 American Institute of Chemical Engineers (AIChE)

引用

页码：266 / 272

页数：7

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