A NONLINEAR VISCOELASTIC MODEL OF LUNG-TISSUE MECHANICS

被引:65
作者
SUKI, B [1 ]
BATES, JHT [1 ]
机构
[1] MCGILL UNIV,MEAKINS CHRISTIE LABS,3626 ST URBAN ST,MONTREAL H2X 2P2,QUEBEC,CANADA
关键词
LUNG TISSUE RESISTANCE AND ELASTANCE; NONLINEAR SYSTEMS ANALYSIS; VOLTERRA SERIES; HARMONIC DISTORTION; PLASTOELASTICITY;
D O I
10.1152/jappl.1991.71.3.826
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
There have been a number of attempts recently to use linear models to describe the low-frequency (0-2 Hz) dependence of lung tissue resistance (Rti) and elastance (Eti). Only a few attempts, however, have been made to account for the volume dependence of these quantities, all of which require the tissues to be plastoelastic. In this paper we specifically avoid invoking plastoelasticity and develop a nonlinear viscoelastic model that is also capable of accounting for the nonlinear and frequency-dependent features of lung tissue mechanics. The model parameters were identified by fitting the model to data obtained in a previous study from dogs during sinusoidal ventilation. The model was then used to simulate pressure and flow data by use of various types of ventilation patterns similar to those that have been employed experimentally. Rti and Eti were estimated from the simulated data by use of four different estimation techniques commonly applied in respiratory mechanics studies. We found that the estimated volume dependence of Rti and Eti is sensitive to both the ventilation pattern and the estimation technique, being in error by as much as 217 and 22%, respectively.
引用
收藏
页码:826 / 833
页数:8
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