EXPRESSION OF SYNAPTOTAGMIN AND SYNTAXIN ASSOCIATED WITH N-TYPE CALCIUM CHANNELS IN SMALL-CELL LUNG-CANCER

被引：38

作者：

DAVID, P

ELFAR, O

MARTINMOUTO, N

POUPON, MF

TAKAHASHI, M

SEAGAR, MJ

机构：

[1] FAC MED SECTEUR N,INSERM,U374,BD PIERRE DRAMARD,F-13916 MARSEILLE 20,FRANCE

[2] INST CURIE,F-75231 PARIS 05,FRANCE

[3] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

来源：

FEBS LETTERS | 1993年 / 326卷 / 1-3期

关键词：

OMEGA-CONOTOXIN; CALCIUM CHANNEL; SYNAPTOTAGMIN; SYNTAXIN; HPC-1; SMALL CELL LUNG CANCER;

D O I：

10.1016/0014-5793(93)81777-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.

引用

页码：135 / 139

页数：5

共 23 条

[1] NCAM - A SURFACE MARKER FOR HUMAN SMALL-CELL LUNG-CANCER CELLS [J].