SYNTHESIS OF A DISULFIDE CROSS-LINKED DNA TRIPLE-HELIX

被引：17

作者：

GOODWIN, JT ^{[1
]}

OSBORNE, SE ^{[1
]}

SWANSON, PC ^{[1
]}

GLICK, GD ^{[1
]}

机构：

[1] UNIV MICHIGAN, DEPT CHEM, ANN ARBOR, MI 48109 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

DISULFIDE CROSS-LINK; DNA TRIPLE HELIX;

D O I：

10.1016/S0040-4039(00)60718-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

引用

页码：4527 / 4530

页数：4

共 32 条

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