INCORPORATION OF ALKYLTHIOL CHAINS AT C-5 OF DEOXYURIDINE

被引:45
作者
GOODWIN, JT [1 ]
GLICK, GD [1 ]
机构
[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109
关键词
ALKYLTHIOL-MODIFIED NUCLEOSIDES; DISULFIDE CROSS-LINKS;
D O I
10.1016/S0040-4039(00)73878-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of alkylthiol-tether homologs at C-5 of 2'-deoxyuridine have been synthesized and incorporated into DNA oligomers through solid-phase DNA phosphoramidite synthesis. DNA-ligand disulfide crosslinks have been initially addressed through formation of an n-butyl-DNA disulfide conjugate.
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页码:5549 / 5552
页数:4
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