HYPOTHESIS ON CELLULAR ATP DEPLETION AND ADENOSINE RELEASE AS CAUSES OF HEART-FAILURE AND VASODILATATION IN CARDIOVASCULAR BERIBERI

被引：23

作者：

BAKKER, SJL

LEUNISSEN, KML

机构：

[1] Department of Nephrology, University Hospital Maastricht, 6202 AZ Maastricht, PO Box 5800

来源：

MEDICAL HYPOTHESES | 1995年 / 45卷 / 03期

关键词：

D O I：

10.1016/0306-9877(95)90115-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cardiovascular beriberi is a syndrome caused by thiamine deficiency and characterized by systemic vasodilatation, heart failure and lactic acidosis. The occurrence of heart failure and vasodilatation is yet unexplained: neither theoretical nor experimental data are known. In this article, it is suggested that a fall of cellular ATP levels causes heart failure and that the release of adenosine is the cause of vasodilatation.

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页码：265 / 267

页数：3

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