ORAL BROMFENAC 10 AND 25 MG COMPARED WITH SUBLINGUAL BUPRENORPHINE 0.2 AND 0.4 MG FOR POSTOPERATIVE PAIN RELIEF

被引：15

作者：

CARROLL, D ^{[1
]}

FRANKLAND, T ^{[1
]}

NAGLE, C ^{[1
]}

MCQUAY, H ^{[1
]}

机构：

[1] UNIV OXFORD,CHURCHILL HOSP,OXFORD & NUFFIELD DEPT ANAESTHET,OXFORD REG PAIN RELIEF UNIT,OXFORD OX3 7LJ,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1993年 / 71卷 / 06期

关键词：

ANALGESICS; NONOPIOID; BROMFENAC; OPIOID; BUPRENORPHINE; PAIN; POSTOPERATIVE;

D O I：

10.1093/bja/71.6.814

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The aim of this single-dose, randomized positive control, double-dummy, double-blind parallel group study was to compare oral bromfenac 10 and 25 mg with sublingual buprenorphine 0.2 and 0.4 mg for treatment of postoperative pain. We studied 91 patients with moderate or severe pain after general surgical or orthopaedic operations, using pain intensity, pain relief, adverse effect, mood and sedation outcomes. There was a significant analgesic dose-response for buprenorphine, showing study sensitivity, but not for bromfenac. The two bromfenac treatments were significantly superior to the two buprenorphine treatments. Significantly more patients reported nausea with buprenorphine. There was evidence of a ceiling effect for analgesia with bromfenac.

引用

页码：814 / 817

页数：4

共 12 条

[1] KETOROLAC - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL [J].