INTERLEUKIN-3 INDUCES TRANSLOCATION AND DOWN-REGULATION OF PROTEIN-KINASE-C IN HUMAN PLATELETS

被引：13

作者：

COOK, PP ^{[1
]}

CHEN, JM ^{[1
]}

WAYS, DK ^{[1
]}

机构：

[1] E CAROLINA UNIV, SCH MED, DEPT MICROBIOL IMMUNOL, GREENVILLE, NC 27858 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91677-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase C (PKC) is a family of phospholipid-dependent kinases that is involved, along with calcium mobilization, in the activation of human platelets. Since interleukin-3 (IL-3) has been shown to act, in part, by activating PKC, we investigated the effect of IL-3 on PKC activity and content in human platelets. Exposure of platelets to 10 ng/ml of IL-3 was associated with a rapid (i.e., within 3 minutes) translocation of PKC activity and content from the cytosol to the membrane fraction. In addition, treatment with IL-3 effected a time-dependent down-regulation of PKC activity and content. We speculate that IL-3 may act as a modulator of PKC-dependent pathways in the human platelet. © 1992.

引用

页码：670 / 675

页数：6

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