DAMAGE TO RED-BLOOD-CELLS INDUCED BY ACOUSTIC CAVITATION

被引：32

作者：

DANIELS, S

KODAMA, T

PRICE, DJ

机构：

[1] Hyperbaric Group, Welsh School of Pharmacy, University of Wales College of Cardiff, Cardiff

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 1995年 / 21卷 / 01期

基金：

英国惠康基金;

关键词：

ULTRASOUND; CAVITATION; BUBBLES; RED BLOOD CELLS; HEMOLYSIS; ABSORPTION SPECTROSCOPY; HEMOGLOBIN;

D O I：

10.1016/0301-5629(94)00089-1

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This experimental study has revealed damage to red blood cells that is quantitatively related to the acoustic pressure during irradiation with 0.75-MHz continuous-wave ultrasound, using a range of intensities comparable to those employed by ultrasonic physiotherapy equipment (0.25 to 7 W cm(-2) spatial average temporal average). Damage to the red blood cells was investigated by measuring the extent of haemolysis using a UV/VIS spectrophotometer. There was a clear correlation between the amount of haemoglobin released and the intensity of harmonic emissions recorded from the sample during irradiation. The observed degree of haemolysis could not be produced by temperature rises in the absence of the sound field. This suggests that the damage was a direct result of acoustic cavitation.

引用

页码：105 / 111

页数：7

共 30 条

[1] ALTMAN PL, 1971, FED AM SOC EXP BIOL, P147
[2] Apfel R. E., 1981, METHODS EXPT PHYSICS, P356
[3] ACOUSTIC CAVITATION PREDICTION
APFEL, RE
[J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1981, 69 (06) : 1624 - 1633
[4] LYSIS OF ERYTHROCYTES BY EXPOSURE TO CW ULTRASOUND
CARSTENSEN, EL
KELLY, P
CHURCH, CC
BRAYMAN, AA
CHILD, SZ
RAEMAN, CH
SCHERY, L
[J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 1993, 19 (02) : 147 - 165
[5] CHANARIN I, 1989, LABORATORY HAEMATOLO, P9
[6] THE KINETICS AND MECHANICS OF ULTRASONICALLY-INDUCED CELL-LYSIS PRODUCED BY NON-TRAPPED BUBBLES IN A ROTATING CULTURE TUBE
CHURCH, CC
MILLER, MW
[J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 1983, 9 (04) : 385 - 393
[7] THE EXPOSURE VESSEL AS A FACTOR IN ULTRASONICALLY-INDUCED MAMMALIAN-CELL LYSIS .2. AN EXPLANATION OF THE NEED TO ROTATE EXPOSURE TUBES
CHURCH, CC
FLYNN, HG
MILLER, MW
SACKS, PG
[J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 1982, 8 (03) : 299 - 309
[8] PHYSICAL AND CHEMICAL ASPECTS OF ULTRASONIC DISRUPTION OF CELLS
CLARKE, PR
HILL, CR
[J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1970, 47 (02) : 649 - &
[9] SONOLUMINESCENCE IN WATER AND AGAR GELS DURING IRRADIATION WITH 0.75 MHZ CONTINUOUS-WAVE ULTRASOUND
DANIELS, S
PRICE, DJ
[J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 1991, 17 (03) : 297 - 308
[10] DANIELS S, 1987, ULTRASOUND MED BIOL, V13, P521

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