THE REFORMATSKY REACTION OF 1-ACYL-3,5-DIMETHYLPYRAZOLES - A CONVENIENT PREPARATION OF 4-AMINO-3-OXOALKANOIC ACID-DERIVATIVES

被引：29

作者：

KASHIMA, C

KITA, I

TAKAHASHI, K

HOSOMI, A

机构：

[1] Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 03期

关键词：

D O I：

10.1002/jhet.5570320303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conversion of N-acylpyrazoles into beta-keto esters was accomplished efficiently by the treatment with alpha-bromo esters and zinc dust. Using this Reformatsky reaction of N-acylpyrazoles, 4-protected amino)-3-oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.

引用

页码：723 / 725

页数：3

共 7 条

[1] SYNTHESIS OF BETA-KETO-ESTERS BY THE REFORMATSKY REACTION OF 3-ACYLOXAZOLIDIN-2-ONES AND 3-ACYLTHIAZOLIDINE-2-THIONES [J].