EFFICIENT CHEMICAL SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING A TRUE ABASIC SITE

被引：22

作者：

PEOCH, D ^{[1
]}

MEYER, A ^{[1
]}

IMBACH, JL ^{[1
]}

RAYNER, B ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,PL EUGENE BATAILLON,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 02期

关键词：

D O I：

10.1016/0040-4039(91)80856-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The photolabile o-nitrobenzyl group has been used to protect the anomeric hydroxyl function of a 2-deoxy-D-ribofuranose building block which was incorporated into DNA oligomers using the standard phosphoramidite method for automated DNA synthesis. The resulting stable o-nitrobenzyl protected oligomers have been purified by HPLC and then quantitatively converted upon long-wavelength UV irradiation into the corresponding abasic DNA sequences (up to 30- mer).

引用

页码：207 / 210

页数：4

共 13 条

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