SYNTHESIS OF (+)-DIHYDROCOMPACTIN AND (+)-COMPACTIN VIA VINYLSILANE TERMINATED CATIONIC CYCLIZATION

被引：21

作者：

BURKE, SD ^{[1
]}

DEATON, DN ^{[1
]}

机构：

[1] UNIV S CAROLINA, DEPT CHEM, COLUMBIA, SC 29208 USA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

MEVINIC ACID TOTAL SYNTHESIS; VINYLSILANE-MEDIATED CATIONIC BICYCLIZATION; BENZENEDIMETHANOL ACETAL INITIATOR;

D O I：

10.1016/S0040-4039(00)92272-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two enantioselective routes to the octalin diol 1 are described, featuring cationic polyene cyclization mediated by a vinylsilane terminating group and a benzenedimethanol acetal initiator. Further transformations resulting informal and total syntheses of (+)-compactin and (+)-dihydrocompactin, respectively, are also reported.

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页码：4651 / 4654

页数：4

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