ENHANCEMENT OF ANTIBIOTIC CONCENTRATIONS IN GASTRIC-MUCOSA BY H-2-RECEPTOR ANTAGONIST - IMPLICATIONS FOR TREATMENT OF HELICOBACTER-PYLORI INFECTIONS

被引:44
作者
WESTBLOM, TU [1 ]
DURIEX, DE [1 ]
机构
[1] MARSHALL UNIV,DEPT MED,INFECT DIS SECT,HUNTINGTON,WV 25701
关键词
GASTRIC MUCOSA; ANTIBIOTICS; H-2-RECEPTOR ANTAGONISTS; GASTRIC ACID SECRETION; HELICOBACTER-PYLORI;
D O I
10.1007/BF01300082
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We measured the effects of cimetidine on antibiotic concentrations in the luminal portion of gastric mucosa. Guinea pigs were premedicated with cimetidine 4 mg/kg intramuscularly. Clindamycin, an antibiotic previously characterized under physiologic pH conditions, was administered intramuscularly and levels measured in serum and tissue using a high-pressure liquid chromatography (HPLC) technique. The luminal mucosa concentration of clindamycin at 1 hr (pH 5.9) was fivefold greater compared to the concentrations seen under physiologic (pH 2.0) conditions (81.5-mu-g/g vs 15.9-mu-g/g; P < 0.05) and 10-fold greater at 2 hr (82.7-mu-g/g vs 8.09-mu-g/g; P < 0.05). There was no difference in peak serum levels between the groups. The finding that an antibiotic with characteristics of a base is thus affected by a nonconservative acid inhibitor such as cimetidine supports the presence of an acidic storage pool as proposed by other investigators. H2-receptor antagonists may be useful therapeutic adjuncts in H. pylori infections by virtue of increasing gastric concentrations of antibiotics that behave as weak bases.
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页码:25 / 28
页数:4
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