FURANOID GLYCAL AS A STARTING MATERIAL FOR NUCLEOSIDE DERIVATIVES

被引：13

作者：

KAWAKAMI, H

EBATA, T

KOSEKI, K

OKANO, K

MATSUMOTO, K

MATSUSHITA, H

机构：

[1] Life Science Research Laboratory, Japan Tobacco Inc., Midori-ku, Yokohama, Kanagawa, 227

来源：

HETEROCYCLES | 1993年 / 36卷 / 12期

关键词：

D O I：

10.3987/COM-93-6503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Furanoid glycal was utilized as a starting material for the nucleoside derivatives with the aid of benzenesulfenyl chloride. Condensation reaction with silylated nucleic bases was high in the presence of SnCl4. Electrophilic addition of benzenesulfenyl chloride to the glycal with substituent also proceeded in high stereoselectivity. Phenylthio-substituted nucleoside was used to convert 2',3'-dideoxynucleoside and 2',3'-didehydro-2',3'-dideoxynucleoside.

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页码：2765 / 2776

页数：12

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