THE ROLE OF HLA CLASS-II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T-LYMPHOCYTES

被引：1

作者：

DEMESOVA, V

BUC, M

FERENCIK, S

SASAZUKI, T

SHAWKATOVA, I

PORUBSKA, S

机构：

[1] UNIV ESSEN GESAMTHSCH KLINIKUM,INST IMMUNOL,W-4300 ESSEN,GERMANY

[2] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1995年 / 22卷 / 06期

关键词：

D O I：

10.1111/j.1744-313X.1995.tb00280.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Investigation of pairs of unrelated persons mismatched for a particular HLA-DQB1 or -DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA-DQ and HLA-DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti-DO and anti-DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA-DQ and HLA-DP antigens play a similar role to HLA-DR specificities in clinical bone marrow transplantation.

引用

页码：425 / 434

页数：10

共 27 条

[1] CELL MEDIATED IMMUNITY - SEPARATION OF CELLS INVOLVED IN RECOGNITIVE AND DESTRUCTIVE PHASES [J].

BACH, FH ;

ZIER, KS ;

SONDEL, PM ;

ALTER, BJ ;

BACH, ML ;

SEGALL, M .

SCIENCE, 1973, 180 (4084) :403-406

[2]

BRADLEY BA, 1980, TISSUE ANTIGENS, V16, P73

[3] HLA-DP ANTIGENS PROVIDE THE PROLIFERATIVE IMPETUS FOR THE GENERATION OF CYTO-TOXIC LYMPHOCYTES-T [J].

BUC, M ;

PORUBSKA, S ;

BENCOVA, M ;

NYULASSY, S ;

STEFANOVIC, J .

TISSUE ANTIGENS, 1988, 32 (05) :291-294

[4]

BUC M, 1978, BRATISLAVSKE LEKARSK, V69, P42

[5]

BUC M, 1975, BRATISLAVSKE LEKARSK, V69, P442

[6]

CESBRON A, 1990, BONE MARROW TRANSPL, V6, P337

[7]

EIJSVOOGEL VP, 1973, TRANSPL P, V5, P415

[8]

HOREJSI V, 1988, TISSUE ANTIGENS, V32, P6

[9]

HOREJSI V, 1986, TISSUE ANTIGENS, V28, P288

[10] MOLECULES INVOLVED IN T-CELL COSTIMULATION [J].

JENKINS, MK ;

JOHNSON, JG .

CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (03) :361-367

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