THE ROLE OF HLA CLASS-II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T-LYMPHOCYTES

被引：1

作者：

DEMESOVA, V

BUC, M

FERENCIK, S

SASAZUKI, T

SHAWKATOVA, I

PORUBSKA, S

机构：

[1] UNIV ESSEN GESAMTHSCH KLINIKUM,INST IMMUNOL,W-4300 ESSEN,GERMANY

[2] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1995年 / 22卷 / 06期

关键词：

D O I：

10.1111/j.1744-313X.1995.tb00280.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Investigation of pairs of unrelated persons mismatched for a particular HLA-DQB1 or -DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA-DQ and HLA-DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti-DO and anti-DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA-DQ and HLA-DP antigens play a similar role to HLA-DR specificities in clinical bone marrow transplantation.

引用

页码：425 / 434

页数：10

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