GLOMERULAR ABNORMALITIES IN CHILDREN UNDERGOING ORTHOTOPIC LIVER-TRANSPLANTATION

被引：14

作者：

CHIN, SE ^{[1
]}

AXELSEN, RA ^{[1
]}

CRAWFORD, DHG ^{[1
]}

ENDRE, ZH ^{[1
]}

LYNCH, SV ^{[1
]}

BALDERSON, GA ^{[1
]}

STRONG, RW ^{[1
]}

SHEPHERD, RW ^{[1
]}

BURKE, JR ^{[1
]}

FLEMING, SJ ^{[1
]}

机构：

[1] ROYAL CHILDRENS HOSP,DEPT GASTROENTEROL & NUTR,BRISBANE,QLD,AUSTRALIA

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 05期

关键词：

GLOMERULONEPHRITIS; LIVER CIRRHOSIS; ORTHOTOPIC LIVER TRANSPLANTATION;

D O I：

10.1007/BF00873994

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A prospective study of renal function was undertaken on an unselected group of 8 children with chronic progressive liver disease on whom a renal biopsy was performed subsequently at the time of orthotopic liver transplantation. Two patients had abnormal urinalyses and 2 elevated urinary albumin/creatinine ratios. The remainder had no clinical evidence of renal dysfunction. All had normal serum creatinine concentrations. Glomerular abnormalities were present in all renal biopsies and were of two types: hepatic glomerulosclerosis (n = 5) and minor glomerular abnormalities (n = 3). IgM immunofluorescence was present in all biopsies and IgA in 6. Elevated serum immunoglobulin levels were observed in all patients, with IgM elevation in 6, IgA in 4 and IgG in 6. C3 and/or C4 were reduced in 5 patients and increased circulating immune complexes containing IgM were noted in 4. The clinical significance of these cirrhosis-associated glomerular abnormalities can only be established by long-term follow-up studies after orthotopic liver transplantation.

引用

页码：407 / 411

页数：5

共 30 条

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