EFFECTS OF TAURINE ON BASAL AND STIMULATED LUTEINIZING-HORMONE (LH) AND LH-RELEASING HORMONE-SECRETION IN OVARIECTOMIZED FATS - IN-VITRO STUDIES

被引：17

作者：

ARIAS, P ^{[1
]}

GOROLL, D ^{[1
]}

CONVERTINI, V ^{[1
]}

JARRY, H ^{[1
]}

WUTTKE, W ^{[1
]}

机构：

[1] GEORGE AUGUST UNIV,FRAUENKLIN,KLIN & EXPTL ENDOKRINOL ABT,GOTTINGEN,GERMANY

来源：

BRAIN RESEARCH | 1994年 / 634卷 / 02期

关键词：

TAURINE; LUTEINIZING HORMONE; PITUITARY CELL CULTURE; LUTEINIZING HORMONE-RELEASING HORMONE; MEDIOBASAL HYPOTHALAMUS; SUPERFUSION; NMDA;

D O I：

10.1016/0006-8993(94)91937-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Taurine (Tau), a putative inhibitory amino acid neurotransmitter, has been shown to inhibit luteinizing hormone (LH) release in vivo. We investigated the effect of this amino acid on LH secretion by cultured anterior pituitary cells. A 5-h incubation with Tau (10(-3)-10(-8) M) did not affect basal or LH-releasing hormone (LHRH)-stimulated LH release. Basal LHRH release from superfused mediobasal hypothalamic fragments was not affected by Tau (10(-3) M). However, this substance clearly diminished LHRH release after stimulation with KCl (50 mM) or N-methyl-D-aspartate (10(-4) M). It is concluded that Tau may exert an inhibitory effect on LH secretion acting at the hypothalamic level.

引用

页码：325 / 327

页数：3

共 16 条

[11]

NISWENDER GD, 1968, P SOC EXP BIOL MED, V128, P807

[12] ACUTE ELEVATIONS OF SERUM LUTEINIZING-HORMONE INDUCED BY KAINIC ACID, N-METHYL ASPARTIC-ACID OR HOMOCYSTEIC ACID [J].

PRICE, MT ;

OLNEY, JW ;

CICERO, TJ .

NEUROENDOCRINOLOGY, 1978, 26 (06) :352-358

[13] LUTEINIZING-HORMONE RELEASING ACTION OF N-METHYL ASPARTATE IS BLOCKED BY GABA OR TAURINE BUT NOT BY DOPAMINE ANTAGONISTS [J].

PRICE, MT ;

OLNEY, JW ;

MITCHELL, MV ;

FULLER, T ;

CICERO, TJ .

BRAIN RESEARCH, 1978, 158 (02) :461-465

[14] STIMULATION OF PROLACTIN SECRETION BY TAURINE, A NEURALLY DEPRESSANT AMINO-ACID [J].

SCHEIBEL, J ;

ELSASSER, T ;

ONDO, JG .

NEUROENDOCRINOLOGY, 1980, 30 (06) :350-354

[15] THE STIMULATION OF PROLACTIN SECRETION BY TAURINE - STUDIES ON THE SITE OF ACTION [J].

SCHEIBEL, J ;

ELSASSER, T ;

BROWN, B ;

DOM, R ;

ONDO, JG .

BRAIN RESEARCH BULLETIN, 1984, 13 (01) :49-52

[16] STIMULATION OF LH-SECRETION AND FSH-SECRETION FOLLOWING INTRAVENTRICULAR-INJECTION OF CYSTEIC ACID BUT NOT TAURINE [J].

SCHEIBEL, J ;

ELSASSER, T ;

ONDO, JG .

BRAIN RESEARCH, 1980, 201 (01) :99-106

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