FAILURE OF CEFOTAXIME TREATMENT IN 2 CHILDREN WITH MENINGITIS CAUSED BY HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE

被引：15

作者：

GUIBERT, M

CHAHIME, H

PETIT, J

ODIEVRE, M

LABRUNE, P

机构：

[1] HOP ANTOINE BECLERE,SERV PEDIAT,F-92141 CLAMART,FRANCE

[2] HOP ANTOINE BECLERE,MICROBIOL LAB,F-92141 CLAMART,FRANCE

[3] HOP MARIE LANNELONGUE,F-92350 LE PLESSIS ROBINS,FRANCE

来源：

ACTA PAEDIATRICA | 1995年 / 84卷 / 07期

关键词：

ANTIBIOTICS; MENINGITIS; STREPTOCOCCUS PNEUMONIAE;

D O I：

10.1111/j.1651-2227.1995.tb13771.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two infants, aged 8.5 and 11 months, were admitted for meningitis caused by Streptococcus pneumoniae. Failure of cefotaxime led to the identification of highly penicillin-G-resistant strains. Minimum inhibitory concentrations (MICs) for penicillin were > 2 mu g/ml, and cefotaxime MICs were 2 mu g/ml. Both patients rapidly responded to a combination of iv imipenem and rifampicin. It is now mandatory to test in-vitro susceptibilities of Streptococcus pneumoniae to penicillin G and other beta-lactam agents when meningitis is diagnosed in infants.

引用

页码：831 / 833

页数：3

共 11 条

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