SINGLE PROGESTERONE ASSAY FOR EARLY RECOGNITION OF ABNORMAL PREGNANCY

被引:40
作者
HAHLIN, M
WALLIN, A
SJOBLOM, P
LINDBLOM, B
机构
[1] Department of Obstetrics and Gynaecology, Sahlgren's Hospital, University of Göteborg, S-413 45, Göteborg
关键词
Diagnosis; Ectopic pregnancy; HCG; Pregnancy; Progesterone;
D O I
10.1093/oxfordjournals.humrep.a137157
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Serum progesterone and human chorionic gonadotrophin (HCG) were analysed using a time-resolved fluoroimmunoassay in an unselected group made up of 158 women with clinical suspicions of abnormal early gestation. Only cases in which endovaginal sonography had failed to localize the pregnancy were included. A single HCG determination had no diagnostic value. On the other hand, a critical progesterone level of 30 nM was determined below which no viable intrauterine pregnancies were found. Eighty-eight per cent of the ectopic pregnancies (n = 97) and 83% of the spontaneous abortions had progesterone levels below this limit. The discriminatory efficacy of one single progesterone determination was independent of the actual HCG level and serial determinations of progesterone did not increase the discriminatory power. © 1990 Oxford University Press.
引用
收藏
页码:622 / 626
页数:5
相关论文
共 27 条
  • [21] Romero R., Kadar N., Jeanty P., Copel J., Chervenat F.A., Dechemey A., Hobbins J.C., Diagnosis of ectopic pregnancy: Value of the discriminatory human chorionic gonadotropin zone, Obstet. Gynecol, 66, pp. 357-360, (1985)
  • [22] Swcts J., ROC-analysis applied to the evaluation of mcdical image techniques, Invest. Radiol, 14, pp. 109-121, (1979)
  • [23] Tanaka T., Hayashi H., Kutsuzawa T., Fujimoto S., Ichinoe K., Treatment of interstitial ectopic pregnancy with methotrexate: Report of a successful case, Fertil. Steril, 37, pp. 851-852, (1982)
  • [24] Thorbum J., Friberg B., Schubert W., Wassen A.C., Lindblom B., Background factors and management of ectopic pregnancy in Sweden. Changes over decade, Acta Obstet. Gynecol, 66, pp. 597-602, (1987)
  • [25] Thorbum J., Philipson M., Lindblom B., Background factors of ectopic pregnancy. II. Risk estimation by means of a logistic model, Eur, J. Obstet. Gynecol. Reprod. Biol, 23, pp. 333-340, (1986)
  • [26] Yeko T.R., Gorrill M.J., Hughes L.H., Rodi I.A., Buster J.E., Sauer M.V., Timely diagnosis of early ectopic pregnancy using a single blood progesterone measurement, Fertil. Steril, 48, pp. 1048-1050, (1987)
  • [27] Yoshimi T., Strott C.A., Marshall J.R., Lipsctt M.B., Corpus luteum function in early pregnancy, J. Clin. Endocrinol, 29, pp. 225-230, (1969)