PREPARATION AND ASSIGNMENT OF CONFIGURATION OF 1-BENZOYL-(2S)-TERT-BUTYL-3-METHYL-PERHYDROPYRIMIDIN-4-ONE - USEFUL STARTING MATERIAL FOR THE ENANTIOSELECTIVE SYNTHESIS OF ALPHA-SUBSTITUTED BETA-AMINO ACIDS

被引:38
作者
JUARISTI, E
QUINTANA, D
机构
[1] Departamento de Química, Centro de Investigación y de Estudios Avanzados, instituto Politécnico Nacional, 07000 México, D.F.
关键词
D O I
10.1016/S0957-4166(00)80511-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
(S) -Asparagine, an inexpensive beta-amino acid was converted into the title heterocycle (+)-1 in very good overall yield. The highly selective trans methylation of (+)-1-Li, and the hydrolysis of the resulting adduct afforded (R)-alpha-methyl-beta-alanine, allowing the assignment of the (S) configuration in (+)-1.
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页码:723 / 726
页数:4
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