PREPARATION AND ASSIGNMENT OF CONFIGURATION OF 1-BENZOYL-(2S)-TERT-BUTYL-3-METHYL-PERHYDROPYRIMIDIN-4-ONE - USEFUL STARTING MATERIAL FOR THE ENANTIOSELECTIVE SYNTHESIS OF ALPHA-SUBSTITUTED BETA-AMINO ACIDS

被引：38

作者：

JUARISTI, E

QUINTANA, D

机构：

[1] Departamento de Química, Centro de Investigación y de Estudios Avanzados, instituto Politécnico Nacional, 07000 México, D.F.

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80511-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(S) -Asparagine, an inexpensive beta-amino acid was converted into the title heterocycle (+)-1 in very good overall yield. The highly selective trans methylation of (+)-1-Li, and the hydrolysis of the resulting adduct afforded (R)-alpha-methyl-beta-alanine, allowing the assignment of the (S) configuration in (+)-1.

引用

页码：723 / 726

页数：4

共 16 条

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