PRECLINICAL AND CLINICAL-STUDIES WITH SOMATOSTATIN RELATED TO THE CENTRAL-NERVOUS-SYSTEM

被引:37
作者
VECSEI, L [1 ]
WIDERLOV, E [1 ]
机构
[1] UNIV LUND,DEPT PSYCHIAT & NEUROCHEM,BOX 638,S-22006 LUND,SWEDEN
关键词
animal behavior; neurochemistry; neurologic disorders; psychiatric disorders; somatostatin;
D O I
10.1016/0278-5846(90)90003-Y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. The tetradecapeptide somatostatin (SS) has a widespread, uneven distribution within several organs including the central nervous system (CNS), with particularly high concentration in the hypothalamus. 2. The SS-related peptides (SS28, SS28(1-12), SS28(15-28)) are originated from the precursor pre-prosomatostatin. 3. SS is suggested to be involved in a large number of CNS functions, locomotion, sedation, excitation, catatonia, body temperature, feeding, nociception, paradoxical sleep, self-stimulation, seizure, learning and memory. 4. SS influences central neurochemical processes. 5. It is possible that SS is related to various neurological and psychiatric illnesses, like Huntington's disease, multiple sclerosis, Parkinson's disease, epilepsy, eating disorders, Alzheimer's disease, schizophrenia and major depressive illness. © 1990.
引用
收藏
页码:473 / 502
页数:30
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