PRECLINICAL AND CLINICAL-STUDIES WITH SOMATOSTATIN RELATED TO THE CENTRAL-NERVOUS-SYSTEM

被引：37

作者：

VECSEI, L ^{[1
]}

WIDERLOV, E ^{[1
]}

机构：

[1] UNIV LUND,DEPT PSYCHIAT & NEUROCHEM,BOX 638,S-22006 LUND,SWEDEN

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1990年 / 14卷 / 04期

关键词：

animal behavior; neurochemistry; neurologic disorders; psychiatric disorders; somatostatin;

D O I：

10.1016/0278-5846(90)90003-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The tetradecapeptide somatostatin (SS) has a widespread, uneven distribution within several organs including the central nervous system (CNS), with particularly high concentration in the hypothalamus. 2. The SS-related peptides (SS28, SS28(1-12), SS28(15-28)) are originated from the precursor pre-prosomatostatin. 3. SS is suggested to be involved in a large number of CNS functions, locomotion, sedation, excitation, catatonia, body temperature, feeding, nociception, paradoxical sleep, self-stimulation, seizure, learning and memory. 4. SS influences central neurochemical processes. 5. It is possible that SS is related to various neurological and psychiatric illnesses, like Huntington's disease, multiple sclerosis, Parkinson's disease, epilepsy, eating disorders, Alzheimer's disease, schizophrenia and major depressive illness. © 1990.

引用

页码：473 / 502

页数：30

共 151 条

[31] FOOD-INTAKE IN RATS IS INCREASED BY INTRACEREBROVENTRICULAR INFUSION OF THE SOMATOSTATIN ANALOG SMS-201-995 AND IS DECREASED BY SOMATOSTATIN ANTISERUM [J].

DANGUIR, J .

PEPTIDES, 1988, 9 (01) :211-213

[32] SOMATOSTATIN ANTISERUM BLOCKS CARBACHOL-INDUCED INCREASE OF PARADOXICAL SLEEP IN THE RAT [J].

DANGUIR, J ;

DESAINTHILAIREKAFI, S .

BRAIN RESEARCH BULLETIN, 1988, 20 (01) :9-12

[33] REVERSAL OF DESIPRAMINE-INDUCED SUPPRESSION OF PARADOXICAL SLEEP BY A LONG-ACTING SOMATOSTATIN ANALOG (OCTREOTIDE) IN RATS [J].

DANGUIR, J ;

KAFI, SD .

NEUROSCIENCE LETTERS, 1989, 98 (02) :154-158

[34] SCOPOLAMINE-INDUCED SUPPRESSION OF PARADOXICAL SLEEP IS REVERSED BY THE SOMATOSTATIN ANALOG SMS-201-995 IN RATS [J].

DANGUIR, J ;

DESAINTHILAIREKAFI, S .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 30 (02) :295-297

[35] ANTERIOR TO POSTERIOR VARIATIONS IN THE CONCENTRATION OF SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN HUMAN BASAL GANGLIA [J].

DAVIES, P ;

JOSEF, J ;

THOMPSON, A .

BRAIN RESEARCH BULLETIN, 1981, 7 (04) :365-368

[36] PHARMACOLOGICAL CHARACTERIZATION OF SCRATCHING BEHAVIOR INDUCED BY INTRA-CRANICAL INJECTION OF SUBSTANCE-P AND SOMATOSTATIN [J].

DOBRY, PJK ;

PIERCEY, MF ;

SCHROEDER, LA .

NEUROPHARMACOLOGY, 1981, 20 (03) :267-272

[37] SOMATOSTATIN AND ANALOGS INHIBIT ENDOGENOUS SYNAPTIC PLASMA-MEMBRANE PROTEIN-PHOSPHORYLATION INVITRO [J].

DOKAS, LA ;

ZWIERS, H ;

COY, DH ;

GISPEN, WH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 88 (2-3) :185-193

[38] FLUPHENAZINE TREATMENT REDUCES CSF SOMATOSTATIN IN PATIENTS WITH SCHIZOPHRENIA - CORRELATIONS WITH CSF HVA [J].

DORAN, AR ;

RUBINOW, DR ;

WOLKOWITZ, OM ;

ROY, A ;

BREIER, A ;

PICKAR, D .

BIOLOGICAL PSYCHIATRY, 1989, 25 (04) :431-439

[39] SOMATOSTATIN CONCENTRATIONS AND BINDING-SITES IN HUMAN FRONTAL-CORTEX ARE DIFFERENTIALLY AFFECTED IN PARKINSONS-DISEASE ASSOCIATED DEMENTIA AND IN PROGRESSIVE SUPRANUCLEAR PALSY [J].

EPELBAUM, J ;

JAVOYAGID, F ;

ENJALBERT, A ;

KRANTIC, S ;

KORDON, C ;

AGID, Y .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1988, 87 (2-3) :167-174

[40] SOMATOSTATIN IN THE CENTRAL-NERVOUS-SYSTEM - PHYSIOLOGY AND PATHOLOGICAL MODIFICATIONS [J].

EPELBAUM, J .

PROGRESS IN NEUROBIOLOGY, 1986, 27 (01) :63-100

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