ANTICOAGULANT ACTIVITY OF AN ANTI-BETA-2-GLYCOPROTEIN-I ANTIBODY IS DEPENDENT ON THE PRESENCE OF BETA-2-GLYCOPROTEIN-I

被引：12

作者：

MATSUDA, J ^{[1
]}

GOHCHI, K ^{[1
]}

TSUKAMOTO, M ^{[1
]}

SAITOH, N ^{[1
]}

ASAMI, K ^{[1
]}

HASHIMOTO, M ^{[1
]}

机构：

[1] SHIMA BIOMED LAB,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 44卷 / 03期

关键词：

AGPI; ANTIPHOSPHOLIPID ANTIBODIES; LUPUS ANTICOAGULANT;

D O I：

10.1002/ajh.2830440309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied whether or not an anti-beta2-glycoprotein) antibody (aGPI) had lupus anticoagulant-like activity, employing the diluted Russel viper venom time (dRVVT) and kaolin clotting time (KCT) as indices. aGPI prolonged the dRVVT and KCT of beta2-glycoprotein I (GPI)-depleted normal plasma in the presence of extrinsic GPI. This prolongation of the dRVVT and KCT occurred immediately after the addition of aGPI and GPI, and was subsequently enhanced further in a time-dependent manner. The GPI/aGPI combinaion was judged to have lupus anticoagulant-like activity by the dRVVT-platelet neutralization test, but this was not confirmed by a lupus anticoagulant-specific test, i.e., the activated partial prothrombin time (APTT) using hexagonal phospholipid. From these findings, it can be concluded that aGPI has lupus anticoagulant-like activity in the presence of GPI, but may be a partially or considerably different antiphospholipid antibody from lupus anticoagulant. Further investigations may be needed to clarify this point. (C) 1993 Wiley-Liss, Inc.

引用

页码：187 / 191

页数：5