AMPLIFICATION OF THE C-ERBB ONCOGENE IS ASSOCIATED WITH MALIGNANCY IN PRIMARY TUMORS OF NEUROEPITHELIAL TISSUE

被引：20

作者：

DIEDRICH, U

SOJA, S

BEHNKE, J

ZOLL, B

机构：

[1] UNIV GOTTINGEN,NEUROCHIRURG KLIN,W-3400 GOTTINGEN,GERMANY

[2] UNIV GOTTINGEN,INST HUMANGENET,W-3400 GOTTINGEN,GERMANY

来源：

JOURNAL OF NEUROLOGY | 1991年 / 238卷 / 04期

关键词：

BRAIN TUMORS; MALIGNANCY GRADE; ONCOGENES; MUTATIONS;

D O I：

10.1007/BF00314785

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In various primary brain tumours of neuroepithelial tissue recombinant DNA techniques were used to demonstrate changes of the epidermal growth factor receptor gene, which is homologous to the c-erbB oncogene. Twenty-one of 40 grade III/IV tumours, but only 1 of 16 grade I/II tumours were found to contain amplified and/or rearranged c-erbB sequences. This highly significant difference suggest that c-erbB amplification, rearrangement, or both, are important steps in malignant transformation in a subset of patients with neuroepithelial tumours.

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页码：221 / 224

页数：4

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