EFFECT OF A RESTRICTED DIET ON THE INVITRO GLUCOSE-INDUCED INSULIN RELEASE OF AGING RATS

被引：6

作者：

CASTRO, M ^{[1
]}

PEDROSA, D ^{[1
]}

OSUNA, JI ^{[1
]}

机构：

[1] UNIV GRANADA,FAC MED,DEPT MED,E-18012 GRANADA,SPAIN

来源：

EXPERIENTIA | 1992年 / 48卷 / 10期

关键词：

D O I：

10.1007/BF01919151

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To study the effect of a sudden loss of body weight on the beta-cell function of aging rats, basal and glucose-induced insulin secretion was measured in pancreatic islets obtained from young (2-month-old), adult (12-month-old) and aging (24-month-old) rats, either fed ad libitum or fed a restricted diet (50 % caloric restriction). Basal insulin secretion was similar in islets of young, adult and older rats. Glucose stimulated insulin release was significantly reduced in aging rats as compared to young animals. Animals fed a restricted diet showed a prolonged and higher secretory rate during first phase release when compared to animals fed ad libitum.

引用

页码：996 / 998

页数：3