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TRANSIENT EXPRESSION OF FGF RECEPTOR-4 MESSENGER-RNA IN THE RAT CEREBELLUM DURING POSTNATAL-DEVELOPMENT

被引：13
作者：
MIYAKE, A
MINAMI, M
SATOH, M
OHTA, M
ITOH, N
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM GENET,KYOTO 60601,JAPAN
[2] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT MOLEC PHARMACOL,KYOTO 60601,JAPAN
[3] NATL UTANO HOSP,CLIN RES CTR,KYOTO 616,JAPAN
来源：
MOLECULAR BRAIN RESEARCH | 1995年 / 31卷 / 1-2期
关键词：
FIBROBLAST GROWTH FACTOR RECEPTOR; MESSENGER-RNA; RAT; BRAIN; CEREBELLUM; GENE EXPRESSION; IN SITU HYBRIDIZATION;
D O I：
10.1016/0169-328X(95)00039-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The fibroblast growth factor (FGF) receptor-4 mRNA in the adult rat brain is expressed preferentially in the medial habenular nucleus. In this paper, we examined the expression of FGFR-4 mRNA in the brain during postnatal development. Interestingly, in addition to the persistent expression of FGFR-4 mRNA in the medial habenular nucleus, FGFR-4 mRNA was transiently expressed in the proliferative zone of the external granule layer of the developing cerebellum. The localization and transient expression of FGFR-4 mRNA in the developing cerebellum suggest that FGFR-4 mRNA was expressed by proliferative granule cells. The present findings indicate that FGFR-4 in the brain has an important role in the postnatal development of the cerebellar cortex.
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页码：95 / 100
页数：6
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