CONTROL OF K+ CHANNELS BY G-PROTEINS

被引：8

作者：

BROWN, AM ^{[1
]}

YATANI, A ^{[1
]}

KIRSCH, G ^{[1
]}

OKABE, K ^{[1
]}

VANDONGEN, AMJ ^{[1
]}

BIRNBAUMER, L ^{[1
]}

机构：

[1] BAYLOR UNIV,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1991年 / 23卷 / 04期

关键词：

G-PROTEINS; K+ CHANNELS; PERTUSSIS TOXIN; MEMBRANE-DELIMITED PATHWAYS; MUSCARINIC RECEPTOR;

D O I：

10.1007/BF00785808

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Heterotrimeric G3 proteins are thought to couple receptors to ionic channels via cytoplasmic mediators such as cGMP in the case of retinal rods, cAMP in the case of olfactory cells, and the cAMP cascade in the case of cardiac myocytes. G protein-mediated second messenger effects on K+ channels are dealt with elsewhere in this series. Recently, membrane-delimited pathways have been uncovered and an hypothesis proposed in which the alpha-subunits of G proteins directly couple receptors to ionic channels, particularly K+ channels. While direct coupling has not been proven, the membrane-delimited nature has been established for specific G proteins and their specific K+ channel effectors.

引用

页码：499 / 507

页数：9

共 59 条

[21] G-PROTEIN BETA-GAMMA-SUBUNITS ACTIVATE THE CARDIAC MUSCARINIC K+-CHANNEL VIA PHOSPHOLIPASE-A2
KIM, D
LEWIS, DL
GRAZIADEI, L
NEER, EJ
BARSAGI, D
CLAPHAM, DE
[J]. NATURE, 1989, 337 (6207) : 557 - 560
[22] ALPHA-SUBUNIT OF GK ACTIVATES ATRIAL K+ CHANNELS OF CHICK, RAT, AND GUINEA-PIG
KIRSCH, GE
YATANI, A
CODINA, J
BIRNBAUMER, L
BROWN, AM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (06): : H1200 - H1205
[23] TRYPSIN ACTIVATION OF ATRIAL MUSCARINIC K+ CHANNELS
KIRSCH, GE
BROWN, AM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (01): : H334 - H338
[24] ARACHIDONIC-ACID METABOLITES AS INTRACELLULAR MODULATORS OF THE G-PROTEIN-GATED CARDIAC K+ CHANNEL
KURACHI, Y
ITO, H
SUGIMOTO, T
SHIMIZU, T
MIKI, I
UI, M
[J]. NATURE, 1989, 337 (6207) : 555 - 557
[25] ON THE MECHANISM OF ACTIVATION OF MUSCARINIC K+ CHANNELS BY ADENOSINE IN ISOLATED ATRIAL CELLS - INVOLVEMENT OF GTP-BINDING PROTEINS
KURACHI, Y
NAKAJIMA, T
SUGIMOTO, T
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1986, 407 (03): : 264 - 274
[26] ACETYLCHOLINE ACTIVATION OF K+ CHANNELS IN CELL-FREE MEMBRANE OF ATRIAL CELLS
KURACHI, Y
NAKAJIMA, T
SUGIMOTO, T
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (03): : H681 - H684
[27] KUROSE H, 1983, J CYCLIC NUCL PROT, V9, P305
[28] SPECIFICITY OF ACTION OF GUANINE NUCLEOTIDE-BINDING REGULATORY PROTEIN SUBUNITS ON THE CARDIAC MUSCARINIC K+ CHANNEL
LOGOTHETIS, DE
KIM, D
NORTHUP, JK
NEER, EJ
CLAPHAM, DE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) : 5814 - 5818
[29] THE BETA-SUBUNIT AND GAMMA-SUBUNIT OF GTP-BINDING PROTEINS ACTIVATE THE MUSCARINIC K+ CHANNEL IN HEART
LOGOTHETIS, DE
KURACHI, Y
GALPER, J
NEER, EJ
CLAPHAM, DE
[J]. NATURE, 1987, 325 (6102) : 321 - 326
[30] MATTERA R, 1989, J BIOL CHEM, V264, P465

← 1 2 3 4 5 6 →