SYNTHESIS OF 1,4-BENZODIAZEPINE-1-CARBOTHIOAMIDES, BICYCLIC ANALOGS OF THE TIBO-TYPE ANTI-HIV AGENTS

被引：8

作者：

LIU, J

DODD, RH

机构：

[1] Institut de Chimie Des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-Sur-Yvette

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 02期

关键词：

D O I：

10.1002/jhet.5570320225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of N'-substituted 1,4-benzodiazepine-1-carbothioamides 2a-j were prepared by reacting the precursor 1,4-benzodiazepine 11 with the corresponding N-substituted isothiocyanates 2a-i or with sodium thiocyanate-trifluoroacetic acid (2j). Despite the structural ressemblance of these molecules with the potent TIBO-type anti-HIV compound R82150, 2a-j displayed no anti-HIV activity in vitro.

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页码：523 / 528

页数：6

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