CD40 LIGAND CD40 DEFICIENCY

被引：20

作者：

CASTIGLI, E ^{[1
]}

FULEIHAN, R ^{[1
]}

RAMESH, N ^{[1
]}

TSITSIKOV, E ^{[1
]}

TSYTSYKOVA, A ^{[1
]}

GEHA, RS ^{[1
]}

机构：

[1] CHILDRENS HOSP,DIV IMMUNOL,BOSTON,MA 02115

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

CD40; LIGAND; ISOTYPE SWITCHING; HIGMX-1; KNOCKOUT;

D O I：

10.1159/000236923

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens.

引用

页码：37 / 39

页数：3

共 6 条

[1] THE CD40 ANTIGEN AND ITS LIGAND
BANCHEREAU, J
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[2] CASTIGLI E, IN PRESS P NAT ACAD
[3] DECREASED EXPRESSION OF THE LIGAND FOR CD40 IN NEWBORN LYMPHOCYTES
FULEIHAN, R
AHERN, D
GEHA, RS
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (08) : 1925 - 1928
[4] MOLECULAR PATHOLOGY OF X-LINKED IMMUNOGLOBULIN DEFICIENCY WITH NORMAL OR ELEVATED IGM (HIGMX-1)
RAMESH, N
FULEIHAN, R
GEHA, R
[J]. IMMUNOLOGICAL REVIEWS, 1994, 138 : 87 - 104
[5] TSITSIKOV E, IN PRESS MOL IMMUNOL
[6] REGULATION OF ISOTYPE SWITCHING
VERCELLI, D
GEHA, RS
[J]. CURRENT OPINION IN IMMUNOLOGY, 1992, 4 (06) : 794 - 797

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