COMPARATIVE EFFECTS OF ANIONIC, NATURAL BILE-ACID SURFACTANTS AND MIXED MICELLES ON THE INTESTINAL-ABSORPTION OF THE ANTHELMINTIC ALBENDAZOLE

被引：19

作者：

DELESTAL, JL ^{[1
]}

ALVAREZ, AI ^{[1
]}

VILLAVERDE, C ^{[1
]}

PRIETO, JG ^{[1
]}

机构：

[1] UNIV LEON,DEPT PHYSIOL PHARMACOL & TOXICOL,E-24071 LEON,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 91卷 / 2-3期

关键词：

ALBENDAZOLE ABSORPTION; INTESTINAL PERFUSION; SURFACTANT; SODIUM TAUROCHOLATE; SODIUM LAURYL SULFATE; MIXED MICELLES;

D O I：

10.1016/0378-5173(93)90329-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intestinal absorption of albendazole using surfactants (sodium taurocholate, sodium lauryl sulfate and mixed micelles) was studied. All experiments were performed on rat small intestine following intestinal perfusion. Solubilization of albendazole with sodium taurocholate improves the absorption constant of albendazole when compared to sodium lauryl sulfate induced solubilization (2.80 and 1.51 h-1, respectively). When mixed micelles (sodium taurocholate-oleic acid) were used the values for the absorption constant obtained (ranging from 1.056 to 1.135 h-1) showed a prevailing effect of oleic acid.

引用

页码：105 / 109

页数：5