GAS-CHROMATOGRAPHIC DETERMINATION OF METHAMPHETAMINE AND ITS METABOLITE AMPHETAMINE IN HUMAN PLASMA AND URINE FOLLOWING CONVERSION TO N-PROPYL DERIVATIVES

被引：30

作者：

JACOB, P ^{[1
]}

TISDALE, EC ^{[1
]}

PANGANIBAN, K ^{[1
]}

CANNON, D ^{[1
]}

ZABEL, K ^{[1
]}

MENDELSON, JE ^{[1
]}

JONES, RT ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,LANGLEY PORTER PSYCHIAT INST,DRUG DEPENDENCE RES CTR,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 664卷 / 02期

关键词：

D O I：

10.1016/0378-4347(94)00479-O

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A gas chromatographic method for the simultaneous determination of methamphetamine and its metabolite amphetamine in human plasma and urine is described. The method utilizes reductive alkylation with propionaldehyde and sodium borohydride to produce N-propyl derivatives, which have excellent chromatographic properties. Structural analogs of the analytes, p-methylmethamphetamine and p-methylamphetamine, are used as internal standards. The method has good precision and accuracy for concentrations ranging from less than 10 ng/ml to 5000 ng/ml and has been used to measure plasma concentrations as part of a pharmacokinetic/pharmacodynamic study of methamphetamine in humans.

引用

页码：449 / 457

页数：9